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Bone Marrow

Bone Marrow

In adult mammals, the bone marrow is the site of B-cell generation and one of the sites of T-cell generation. It is also produces erythrocytes, granulocytes, monocytes, and platelets. Early on it was discovered that when the spleen (another major component of the immune system) was irradiated, it was depleted of cells. However, when it was reconstituted with bone marrow cells, it soon began to develop colonies on it. After some time it recovered its appearence and function. This was a strong indication that the bone marrow was responsible for generating the stem-cells which give rise to all the other immune cells. It was found that the bone marrow was the place where the maturation of B-lymphocytes occured. However an irradiated animal needed to have a thymus for the bone marrow cell therapy to work. It was soon discovered that only immature "pre-T" cells are generated in the bone marrow. Their maturation takes place in the thymus.

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